taxane相关论文
Potential role of pemetrexed in metastatic breast cancer patients pretreated with anthracycline or t
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临床使用的Taxane有紫杉醇和多西他赛。由于传统药物不能延长存活时间 ,迄今症状性激素非依赖性抗前列腺癌 (HRPC)化疗仍为姑息性......
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Clinical Implications of HER-2 and P53 in Taxane-Based and Anthracycline-Based Neoadjuvant Chemother
OBTECTIVE To evaluate the predictive value of human epidermal growth factor receptor-2(HER-2)and P53 in taxane-based and......
Objective:Anthracycline and taxane are the standard agents in combined chemotherapy of advanced breast cancer.However,wh......
Liquid chromatography(LC) is considered by many as a mature technique.Nonetheless,LC technology continues to evolve driv......
Clinical Implications of HER-2 and P53 in Taxane-Based and Anthracycline-Based Neoadjuvant Chemother
OBTECTIVE To evaluate the predictive value of human epidermal growth factor receptor-2(HER-2)and P53 in taxane-based and......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Facile Synthesis of 7-epi-Taxane and Its Derivatives and Preliminary Evaluation of Anticancer Activi
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探讨紫杉烷类化合物的抗氧化应激作用,选择适当浓度双氧水处理神经母细胞瘤细胞(SK-N-SH)建立氧化应激细胞模型,用自红豆杉科的......
A highly regioselective O-deacetylation of taxanes at C-5 position was accomplished by treatment with t-BuOK and a possi......
目的观察吉西他滨联合氟尿嘧啶（5-FU）治疗对紫杉醇类、顺铂耐药的晚期卵巢癌的疗效和不良反应。方法2005—02～2011-12用吉西他滨1000m......
<正>The discovery of taxol (2) possessing clinical activities against ovarian and breast cancer has stimulated a wide in......
目的探讨紫杉烷类所致相关指（趾）甲损伤的危险因素。方法 2008～2013年,对我院肿瘤科收治的200名肿瘤化疗患者进行了前瞻性分析。从化......
紫杉醇是临床效果最好的抗癌药物之一。其主要来源于红豆杉提取、全合成与半合成。利用微生物转化其副产物能提高红豆杉利用率。转......
为探讨紫杉烷类化合物的抗氧化应激作用,选择适当浓度双氧水处理神经母细胞瘤细胞(SK-N-SH)建立氧化应激细胞模型,用自红豆杉科的......
对国内外主要红杉资源植物中ｔａｘｏｌ，ｃｅｐｈａｌｏｍａｎｎｉｎｅ，ｂａｃｃａｔｉｎⅢ和１０－ｄｅａｃｅｔｙｌｂａｃｃａｔｉｎⅢ四种红豆杉烷进行了含量测定。结果表明，ｔａｘｏｌ含量以加拿大短叶红豆杉树皮中最高，中间红豆杉次之，我国东......
目的：从中国红豆杉细胞培养物提取紫杉烷类二萜化合物。方法：95%乙醇提取，溶剂萃取，硅胶柱层析，重结晶。结果和结论：首次从中国红豆杉细......
从福建产的美丽红豆杉(Taxus mairei)心木中分离得四个紫杉烷二萜。其结构分别为1-去羟基巴苦亭Ⅵ(1-dehydroxy-baccatin Ⅵ,1),巴......
Despite numerous advances in treatment options,advanced gastric cancer(AGC)remains a major public health issue and the l......
利用细胞培养生产此杉醇是重要的生产途径之一，但是，由于紫杉醇含量低，已经成为世界级研究难题。因此，紫杉醇的生物合成调控成为研究热......
植物生长调节物质不但控制细胞分裂，也影响着紫杉醇或紫杉烷类化合物的合成，５ｍｇ／Ｌ ＮＡＡ、１ｍｇ／Ｌ ＢＡ有利于紫杉愈伤组织的生长。随着ＢＡ深度伯提高，愈伤组......
研究了水杨酸对中国红豆杉细胞培养生产紫杉烷的影响.结果表明,适宜浓度的水杨酸对不同的紫杉烷的合成均有明显的促进作用.......
近年已有许多研究以天然紫杉烷为底物进行微生物转化，这些微生物不仅可以选择性地氧化母核的1、6、7、9、10、14、17和20位，还可以使......
从加拿大红豆杉（Taxus canademis）的扦插苗中分离出三个紫杉烷二萜化合物1—3，用一维和二维核磁共振技术鉴定它们的化合物结构，并根据H......
目的 系统评价紫杉类联合蒽环类药物及环磷酰胺新辅助化疗方案（TEC/TAC）治疗乳腺癌的疗效及安全性.方法 采用计算机检索和手工检索相......
目的探讨复发转移性乳腺癌组织中Tau蛋白的表达情况及其与紫杉醇药物姑息性化疗敏感性的相关性。方法采用免疫组化Envision二步法......
目的：探讨晚期乳腺癌中DNA拓扑异构酶-Ⅱα（ TopoⅡα）、人类表皮生长因子受体-2（ Her-2）的表达对紫杉类药物化疗敏感性的预测价值。方......
目的探讨长春瑞滨联合顺铂方案治疗蒽环及紫杉类耐药晚期乳腺癌的疗效。方法将60例蒽环及紫杉类耐药的晚期乳腺癌患者随机分为观察......
The Akt signal transduction pathway controls most hallmarks of cancer.Activation of the Akt cascade promotes a malignant......
由偶氮二异丁腈引发次磷酸产生次磷酸根自由基，以链式自由基反应机制脱除紫杉烷类化合物结构中的含氧基团，简单、高效地合成了紫杉烷......
目的研究蒽环类联合紫杉类化疗药新辅助化疗方案治疗乳腺癌的临床疗效和安全性。方法选取2012年1月至2013年6月我院收治的76例乳腺......
为了研究接受放化疗后的患者在应用紫杉类药物后肺炎的发生率是否会增加。笔者回顾性研究2004年9月到2015年6月接受紫杉类药物治疗......
Occurrence of myelodysplastic syndrome during paclitaxel- and carboplatin-based chemotherapy for rec
Platinum and taxane have significant activity as key drugs in current treatment of advanced ovarian cancer. While myelod......
Introduction: The incidence of ocular metastasis from Breast Carcinoma is only between 5% - 30%, mainly located in choro......
A 50-year-old woman presented with a 1-week history of rash on the face and hands and difficulty when rising from a sitt......
A 50-year-old woman presented with a 1-week history of rash on the face and hands and difficulty when rising from a sitt......
Background: Metastatic breast cancer in BRCA 2 patients is lacking of target therapy studies. Case: We present a case of......
随着自然科学的发展,催生了21世纪工程学和生物科学交叉领域的合成生物学。当前,合成生物学广泛应用于环境、可再生能源、人体健康......
本文以邻＝肖基苯辛醚（ＮＰＯＥ）为液相基体，纤维纸为基底，用基体辅助激光解吸／电离飞行时间质谱法（ＭＡＬＤＩ－ＴＯＦ－ＭＳ）测定紫杉烷类化合物，研究其激光裂解规律。......
Breakthrough therapy for peritoneal carcinomatosis of gastric cancer:Intraperitoneal chemotherapy wi
The effect of chemotherapy on peritoneal carcinomatosis(PC) of gastric cancer remains unclear.Recently,the intraperitone......
南方红豆杉是我国提取抗癌药紫杉醇的原料植物之一。但分布在于不同地区的南方红豆杉其紫杉醇含量差异很大。应用ＲＡＰＤ技术，用２１个引物共扩......
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A highly regioselective O-deacetylation of taxanes at C-5 position was accomplished by treatment with t-BuOK and a possi......
新 abeotaxane 从 Taxus mairei.Its 的种子被孤立结构被决定到 be2alpha， 5alpha,13alpha-trihydroxy-7beta,10beta-diacetoxy-2 (......
Reduction of 1-deoxy-13-oxotaxanes has been studied under different reaction conditions.Some interesting reactions were ......
An unusual formation of cyclic sulfite at C-4 and C-5 positions of taxane was accomplished by treatment of compound 1 wi......
The use of radio frequency energy is an established technology for certain oncology therapies. Direct inputs of radio fr......
